Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP
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منابع مشابه
PLATELETS AND THROMBOPOIESIS Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP
The role of the Wiskott-Aldrich syndrome protein (WASp) in platelet function is unclear because platelets that lack WASp function normally. WASp constitutively associates with WASp-interacting protein (WIP) in resting and activated platelets. The role of WIP in platelet function was investigated using mice that lack WIP or WASp. WIP knockout (KO) platelets lack WASp and thus are double deficien...
متن کاملPlatelet-associated IgAs and impaired GPVI responses in platelets lacking WIP.
The role of the Wiskott-Aldrich syndrome protein (WASp) in platelet function is unclear because platelets that lack WASp function normally. WASp constitutively associates with WASp-interacting protein (WIP) in resting and activated platelets. The role of WIP in platelet function was investigated using mice that lack WIP or WASp. WIP knockout (KO) platelets lack WASp and thus are double deficien...
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We have investigated the density of the collagen receptors glycoprotein VI (GPVI) and 2 1 on human platelets and their relationship to polymorphisms within the GPVI gene. GPVI levels varied 1.5-fold and showed a weak correlation (r 0.35) with the levels of 2 1, which varied 3-fold. GPVI genotype had a significant effect on receptor levels with carriers of the proline 219 allele (approximately 2...
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ژورنال
عنوان ژورنال: Blood
سال: 2009
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2009-02-202721